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Science 352, 899–901; 2016); preprints can be posted Anytime during the peer review method. Submitting of preprints is just not considered prior publication and will likely not jeopardize consideration at Springer journals. Manuscripts posted on preprint servers won't be taken under consideration when pinpointing the progress supplied by a review into account in a Springer journal.
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It truly is hard to specify a threshold at which a economical interest will become important, any these kinds of determine is always arbitrary, so a person feasible sensible guideline is the following: "Any undeclared economical fascination that would embarrass the author were it to become publicly regarded once the function was revealed."